Invasive candidiasis trial supports echinocandins for primary therapy
نویسندگان
چکیده
منابع مشابه
Echinocandins - first line in invasive candidiasis: how strong is this 'strong' evidence?
[1] published a post hoc analysis of a randomized controlled trial comparing the effi cacy of anidulafungin versus fl uconazole in non-neutropenic critically ill patients with invasive Candida infections (89% had candidemia). But the authors’ claim that their data support the superiority of anidula fungin may be misleading and raises several concerns. First, the primary endpoint of the study wa...
متن کاملBiomarker-guided antifungal stewardship policies for patients with invasive candidiasis
Invasive fungal infections (IFIs) are among the life-threatening issues in patients with impaired immune system. High administration of antifungals in these patients imposes a heavy economic burden on the national health system. In addition, despite the usually expensive antifungal regimens, the mortality rate due to fungal infections is still high, resulting in the loss of hundreds of lives pe...
متن کاملRisk for invasive fungal infections during acute myeloid leukemia induction therapy: a true association with echinocandins?
We acknowledge the letter of Marini and colleagues (1), in which the authors raise several issues with regard to our epidemiological analysis of invasive fungal infections (IFIs) among patients receiving antifungal prophylaxis during initial remission induction chemotherapy (RIC) for acute myeloid leukemia (AML) (2). Specifically, they suggest that our findings are inconsistent with those of ra...
متن کاملCost-effectiveness of three echinocandins and fluconazole in the treatment of candidemia and/or invasive candidiasis in nonneutropenic adult patients
OBJECTIVE To estimate the cost-effectiveness of three echinocandins (anidulafungin, caspofungin, and micafungin) and generic fluconazole in the treatment of nonneutropenic adult patients with candidemia and/or invasive candidiasis in intensive care units in Spain. MATERIALS AND METHODS A decision-tree model was applied. The success and safety (hepatic and renal adverse effects) of first-line ...
متن کاملPharmacoeconomic analysis of antifungal therapy for primary treatment of invasive candidiasis caused by Candida albicans and non-albicans Candida species
BACKGROUND Cost-effectiveness studies of echinocandins for the treatment of invasive candidiasis, including candidemia, are rare in Asia. No study has determined whether echinocandins are cost-effective for both Candida albicans and non-albicans Candida species. There have been no economic evaluations that compare non-echinocandins with the three available echinocandins. This study was aimed to...
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ژورنال
عنوان ژورنال: Annals of Infection
سال: 2019
ISSN: 2616-2709
DOI: 10.21037/aoi.2019.07.02